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Unlike in Navigate to... feature where the route is calculated from start to end by a routing service, Navigation along a route navigates recorded tracks, imported or planned routes stored in your own Locus track/route database.
Locus Map automatically generates navigation commands along the route in places of the most remarkable direction changes.
If you need to be navigated in reverse direction, make a copy of the route and check both the Change track orientation and Generate commands options in the copy dialog.
Auto-recalculation with point priority ignores your selected route and creates a new route to the nearest via point or directly to the finish.